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Sigma-Aldrich

Nε-Trifluoroacetyl-L-lysine

≥96.0% (TLC)

Synonym(s):

ε-TFA-lysine

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About This Item

Empirical Formula (Hill Notation):
C8H13F3N2O3
CAS Number:
Molecular Weight:
242.20
Beilstein:
2122429
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

Assay

≥96.0% (TLC)

form

powder

impurities

≤7% water

color

white to off-white

mp

>215 °C

solubility

2 M HCl: 10 mg/mL, clear, colorless

application(s)

peptide synthesis

storage temp.

2-8°C

SMILES string

N[C@@H](CCCCNC(=O)C(F)(F)F)C(O)=O

InChI

1S/C8H13F3N2O3/c9-8(10,11)7(16)13-4-2-1-3-5(12)6(14)15/h5H,1-4,12H2,(H,13,16)(H,14,15)/t5-/m0/s1

InChI key

PZZHRSVBHRVIMI-YFKPBYRVSA-N

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Biochem/physiol Actions

Nε-Trifluoroacetyl-L-lysine is an inhibitor of L-lysine cyclodeaminase.
Nε-Trifluoroacetyl-L-lysine may be used to create synthetic organic polypeptides useful for nonaqueous capillary electrophoresis (NACE).

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hervé Cottet et al.
Analytical chemistry, 75(20), 5554-5560 (2004-01-09)
Poly(Nepsilon-trifluoroacetyl-L-lysine) was used as a model solute to investigate the potential of nonaqueous capillary electrophoresis (NACE) for the characterization of synthetic organic polymers. The information obtained by NACE was compared to that derived from size exclusion chromatography (SEC) experiments, and
Min He et al.
Gene, 377, 109-118 (2006-06-30)
Meridamycin is a non-immunosuppressive, FKBP12-binding natural macrolide with potential therapeutic applications in a variety of medical conditions. To set the stage for structural modification of meridamycin by genetic engineering, we have cloned and completely sequenced approximately 117 kb of DNA
Determination of synthetic polypeptide conformations and molecular geometrical parameters by nonaqueous CE.
Plasson R, Vayaboury W, Giani O, Cottet H.
Electroanalysis, 28, 3617-3624 (2007)
Laurent Geiser et al.
Electrophoresis, 30(1), 36-49 (2008-12-25)
This review article presents recent developments and applications of non-aqueous capillary electrophoresis (NACE): The text covers the period from the previous review (L. Geiser, J. L. Veuthey, Electrophoresis 2007, 28, 45-57) to summer 2008. We focus primarily on the analysis
Qixian Chen et al.
ACS applied materials & interfaces, 8(37), 24404-24414 (2016-09-01)
Nucleic acid-based therapy has emerged as a revolutionary methodology for treatment of the diseases related to protein dysfunction; however, lack of systemically applicable synthetic delivery systems limits its current usage in local applications, particularly for DNA-based therapy with regard to

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