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Merck

CDK7

cyclin-dependent kinase 7

Synonyms:
CAK1, CDKN7, HCAK, MO15, STK1, p39MO15
Species:
UniProtKB ID:
Gene ID:
  • Human(1022) Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
  • Mouse(12572) cyclin-dependent kinase 7
  • Rat(171150) cyclin-dependent kinase 7
  • domestic guinea pig(100725955) cyclin-dependent kinase 7
  • naked mole-rat(101702664) cyclin-dependent kinase 7
  • sheep(101119934) cyclin-dependent kinase 7
  • Horse(100049964) cyclin-dependent kinase 7
  • Zebrafish(405897) cyclin-dependent kinase 7
  • dog(608441) cyclin-dependent kinase 7
  • domestic cat(101086781) cyclin-dependent kinase 7
  • chicken(771294) cyclin-dependent kinase 7
  • cow(515462) cyclin-dependent kinase 7
  • fruit fly(31441) Cyclin-dependent kinase 7

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho Cyclin-dependent kinase 7 (Thr170) Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse, rat
Application
ChIP
western blot
Anti-phospho-CDK7 (pThr170) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-CDK7 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-CDK7 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry

western blot
Monoclonal Anti-CDK7 antibody produced in mouse, clone 1G5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA

Small Molecule - Inhibitor

Product Number
Description
Species
Flavopiridol hydrochloride hydrate, ≥98% (HPLC), powder,
Species
human
Roscovitine, ≥98% (TLC),
Species
human, mouse, rat
Olomoucine, ≥98% (HPLC),
Species
human, rat

Proteins

Product Number
Description
Species
Cdk7/Cyclin H/MAT1 (CAK complex) Protein, active, 10 µg, Active complex of recombinant full length human Cdk7, containing a C-terminal His6-tag, recombinant full-length human Cyclin H untagged & recombinant full-length human MAT1 containing an N-terminal GST-tag, for use in Kinase Assays.,
Species
human
CDK7/Cyclin H1/MNAT1, active, His tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Cdk7,
Species
mouse
MISSION® esiRNA, targeting human CDK7,
Species
human

Small Molecule - Substrate

Product Number
Description
Species
Cdk7/9tide, ,
Species
human