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  • Allergy to methyldibromoglutaronitrile/phenoxyethanol (Euxyl k 400): regulatory issues, epidemiology, clinical characteristics, and management.

Allergy to methyldibromoglutaronitrile/phenoxyethanol (Euxyl k 400): regulatory issues, epidemiology, clinical characteristics, and management.

Dermatitis : contact, atopic, occupational, drug (2011-05-17)
Angela E Aakhus, Erin M Warshaw
ABSTRACT

Methyldibromoglutaronitrile/phenoxyethanol (Euxyl K 400) is a preservative found in both personal care products and industrial sources. Although Euxyl K 400 initially appeared to have low sensitizing potential, increased prevalence of contact allergy to Euxyl K 400 led to regulatory intervention. This review summarizes the history, epidemiology, and management of contact allergy to Euxyl K 400. Issues related to patch-test preparations are also discussed.

MATERIALS
Product Number
Brand
Product Description

Supelco
2-Phenoxyethanol, Pharmaceutical Secondary Standard; Certified Reference Material
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Supelco
Methyldibromoglutaronitrile, analytical standard
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Supelco
2-Phenoxyethanol, analytical standard
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Sigma-Aldrich
2-Phenoxyethanol, ≥99%
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Availability
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Sigma-Aldrich
Ethylene glycol monophenyl ether, ≥90%
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USP
Phenoxyethanol, United States Pharmacopeia (USP) Reference Standard
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Phenoxyethanol, European Pharmacopoeia (EP) Reference Standard
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