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G3018

Sigma-Aldrich

Asialoganglioside GM1 from bovine brain

~98%, lyophilized powder

Synonym(s):

Ceramide tetrahexoside, Ganglioside GM1, asialo, Gangliotetraosyl ceramide

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About This Item

CAS Number:
71012-19-6
MDL number:
MFCD00131128
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

~98%

Quality Level

200

form

lyophilized powder

storage temp.

−20°C

InChI

1S/C62H114N2O23/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-46(71)64-40(41(70)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)38-80-60-54(78)51(75)57(44(36-67)83-60)86-62-55(79)52(76)56(45(37-68)84-62)85-59-47(63-39(3)69)58(49(73)43(35-66)81-59)87-61-53(77)50(74)48(72)42(34-65)82-61/h30,32,40-45,47-62,65-68,70,72-79H,4-29,31,33-38H2,1-3H3,(H,63,69)(H,64,71)/b32-30+/t40?,41?,42-,43-,44-,45-,47-,48+,49+,50+,51-,52-,53-,54-,55-,56+,57-,58-,59+,60?,61+,62+/m1/s1

InChI key

VELGMVLNORPMAO-JTFNWEOFSA-N

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Amino Acid Sequence

Cer-Glc-Gal-GalNAc-Gal

General description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialylated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Biochem/physiol Actions

Removing the sialic acid from monosialoganglioside GM1 inhibits its ability to bind cholera toxin. Asialoganglioside GM1 does not block the binding of cholera toxin to cellular GM1.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gui-Hua Jin et al.
International immunology, 20(6), 783-789 (2008-05-02)
Combination treatment consisting of IL-2 together with anti-IL-2 mAbs results in markedly larger increases in the numbers of CD8(+) T cells, dendritic cells (DCs) and NK cells in vivo compared with the results observed with injections of IL-2 or the
Hideto Nishikado et al.
Journal of immunology (Baltimore, Md. : 1950), 186(10), 5766-5771 (2011-04-15)
NK cells are innate immune lymphocytes and play a key role in both innate and adaptive immunity. Their pivotal functions in vivo have been illustrated in mice by means of their ablation with NK cell-depleting Abs, particularly anti-asialo GM1 (ASGM1).
A Abulrob et al.
Journal of microscopy, 232(2), 225-234 (2008-11-20)
The localization of asialo-GM1 in ordered membrane raft domains in HeLa cells has been examined using a combination of membrane fractionation and fluorescence imaging. The glycolipid is enriched in Triton X-100 insoluble membrane fractions that contain high concentrations of cholesterol
Adam W Mailloux et al.
International journal of cancer, 127(11), 2598-2611 (2010-03-04)
Tumor-induced immune suppression involves the accumulation of suppressive infiltrates in the tumor microenvironment such as regulatory T-cells (Tregs). Previous studies demonstrated that NK-dependant increases in CCL22 secretion selectively recruit Tregs toward murine lungs bearing Lewis Lung Carcinoma (LLC). To extend
Masao Iwamori et al.
Glycoconjugate journal, 28(1), 21-30 (2010-12-22)
In the digestive tract of mice (HR-1, 5 months old, ♀), asialo GM1 (GA1) exhibiting receptor activity toward several intestinal bacteria was preferentially expressed in the small intestine. Also, less than 10% of GA1 in the small intestine was converted
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