F9786
Fibroblast Growth Factor-Basic Heparin Stabilized human
recombinant, expressed in E. coli, aqueous solution, suitable for cell culture
Synonym(s):
rhbFGF
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product name
Fibroblast Growth Factor-Basic Heparin Stabilized human, FGF-Basic, recombinant, expressed in E. coli, sterile-filtered, aqueous solution, suitable for cell culture
biological source
human
Quality Level
recombinant
expressed in E. coli
sterility
sterile-filtered
form
aqueous solution
potency
0.03-3.0 ng/mL ED50/EC50
quality
endotoxin tested
packaging
pkg of 1 and 5 mL
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... FGF2(2247)
General description
Fibroblast growth factor 2 (FGF2), a canonical member, belongs to the fibroblast growth factor family.
Application
Fibroblast Growth Factor-Basic Heparin Stabilized human has been used to culture Brown Norway rat yolk sac epithelial cells transformed with mouse sarcoma virus (BN/MSV). It has also been used in the preparation of serum-free mouse tubal epithelium growth medium (M-TE-GM) to culture primary tubal epithelium (TE) cells.
Biochem/physiol Actions
Fibroblast growth factor 2 (FGF2) participates in tissue development and repair. It is also involved in embryonic development, angiogenesis, bone regeneration, stem cell self-renewal, and wound healing. The basic fibroblast growth factor (bFGF) plays a key role in the progression and maintenance of the nervous system. FGF2 binds to the FGF receptor (FGFR) and activates the extracellular signal-regulated kinase (ERK) pathway, which controls cellular behavior, using heparan sulfates (HS)/heparin as a cofactor. bFGF stimulates cell proliferation, differentiation, and migration in a variety of cell types. In cultured astrocytes from rat brain, recombinant human basic fibroblast growth factor (rhbFGF) may induce nerve growth factor (NGF) secretion. It is the heparin stabilized form of a natural mitogenic growth factor used in cell culture applications to study cell signaling and to promote fibroblast and endothelial cell growth and survival.
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Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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