Skip to Content
Merck
All Photos(1)

Key Documents

B57001

Sigma-Aldrich

2-Bromobenzaldehyde

98%

Synonym(s):

2-Formylbromobenzene

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
BrC6H4CHO
CAS Number:
Molecular Weight:
185.02
Beilstein:
636132
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

98%

form

liquid

refractive index

n20/D 1.595 (lit.)

bp

230 °C (lit.)

mp

16-19 °C (lit.)

density

1.585 g/mL at 25 °C (lit.)

SMILES string

Brc1ccccc1C=O

InChI

1S/C7H5BrO/c8-7-4-2-1-3-6(7)5-9/h1-5H

InChI key

NDOPHXWIAZIXPR-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

2-Bromobenzaldehyde is a versatile building block used in Suzuki-Miyaura and Buchwald-Hartwig reactions, cross-coupling reactions to form carbon-carbon or carbon-heteroatom bonds

Application

Synthetic applications of 2-bromobenzaldehyde include:
  • Synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction.
  • Preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.
  • It is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.
  • Palladium/copper-catalyzed coupling and cyclization of terminal acetylenes derived from 2-bromobenzaldehyde and unsaturated imines can be used in the synthesis of wide range of isoquinolines, including decumbenine B.
  • Fluoren-9-ones can be synthesized by annulation of arynes, generated in situ from 2-(trimethylsilyl)aryl triflates, with 2-bromobenzaldehyde in the presence of palladium(0) catalyst.
  • It can also be used to build a variety of steroid frameworks, in which ring A is derived from 2-bromobenzaldehyde.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

203.0 °F - closed cup

Flash Point(C)

95 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

A gold-catalyzed domino process to the steroid framework.
Hildebrandt D and Dyker G
The Journal of Organic Chemistry, 71(18), 6728-6733 (2006)
Assembly of N, N-Disubstituted Hydrazines and 1-Aryl-1 H-indazoles via Copper-Catalyzed Coupling Reactions.
Xiong X, et al.
Organic Letters, 14(10), 2552-2555 (2012)
Synthesis of isoquinolines and pyridines by the palladium/copper-catalyzed coupling and cyclization of terminal acetylenes and unsaturated imines: the total synthesis of decumbenine B.
Roesch K R and Larock R C
The Journal of Organic Chemistry, 67(1), 86-94 (2002)
Enantioselective total synthesis of (?)-taxol.
Kusama H, et al.
Journal of the American Chemical Society, 122(16), 3811-3820 (2000)
Palladium-catalyzed one-pot Suzuki-Miyaura cross coupling followed by oxidative lactonization: a novel and efficient route for the one-pot synthesis of benzo [c] chromene-6-ones
R Singha, et al.
Tetrahedron Letters, 54, 657-660 (2013)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service