D-115

Doxepin-D₃ (cis/trans) hydrochloride solution

1.0 mg/mL in methanol (as free base), certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₉H₁₈D₃NO · HCl
• CAS Number: 347840-07-7
• Molecular Weight: 318.86
• MDL number: MFCD01074151
• UNSPSC Code: 41116107
• PubChem Substance ID: 329798673
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL in methanol (as free base)
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: CN(C([2H])([2H])[2H])CC/C=C1C2=C(C=CC=C2)COC3=C/1C=CC=C3.[H]Cl
• InChI: 1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11-;/i1D3;
• InChI key: MHNSPTUQQIYJOT-JSMHCMNYSA-N

Description

General description

Doxepin is a tricyclic antidepressant used for the treatment of sleep maintenance. This internal standard is applicable for doxepin testing or isotope dilution methods by GC/MS or LC/MS for clinical toxicology, urine drug testing, or forensic analysis applications.

Application

• High-throughput protein precipitation method for doxepin analysis: A study presented a protein precipitation method using a 96-well plate to determine doxepin and nordoxepin levels in human plasma, employing LC-MS/MS, highlighting the utility of stable isotope-labeled doxepin for quantitative analysis in clinical settings (Margaryan et al., 2020).


• LC-MS-MS analysis of neuroleptics including doxepin: Research detailed the use of LC-MS-MS for analyzing neuroleptics like doxepin in hair samples from psychiatric patients, demonstrating the method′s effectiveness for long-term medication monitoring (Weinmann et al., 2002).


• Detection of doxepin in hair following therapy: A study investigated the detection of doxepin and its major metabolite in hair, providing a methodological foundation for forensic and clinical assessments of drug therapy adherence using hair samples (Negrusz et al., 1998).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup