- O-TBS-N-tosylhydroxylamine: a reagent for facile conversion of alcohols to oximes.
O-TBS-N-tosylhydroxylamine: a reagent for facile conversion of alcohols to oximes.
Organic letters (2008-05-01)
Katsushi Kitahara, Tatsuya Toma, Jun Shimokawa, Tohru Fukuyama
PMID18444657
ABSTRACT
A variety of oximes were synthesized from the corresponding alcohols, alkyl halides, or alkyl sulfonates without using external oxidants. With this simple two-step procedure involving substitution with readily available TsNHOTBS and subsequent treatment with CsF, a range of oximes were prepared including the ones hardly preparable with conventional procedures.
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