P5155

D-Pantothenic acid hemicalcium salt

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

• Synonym(s): (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt, Calcium D-pantothenate, Vitamin B₅
• Linear Formula: HOCH₂C(CH₃)₂CH(OH)CONHCH₂CH₂CO₂ ·1/2Ca
• CAS Number: 137-08-6
• Molecular Weight: 238.27
• Beilstein: 3769272
• EC Number: 205-278-9
• MDL number: MFCD00002766
• UNSPSC Code: 12352205
• eCl@ss: 34058012
• PubChem Substance ID: 24898601
• NACRES: NA.75

Properties

• biological source: synthetic (organic)
• product line: BioReagent
• Assay: ≥98% (TLC)
• form: powder
• mol wt: M_w 238.27 g/mol
• technique(s): cell culture | insect: suitable; cell culture | mammalian: suitable; cell culture | plant: suitable
• color: white to off-white
• pH: 7.0-8 (25 °C, 50 g/L)
• solubility: water: soluble 50 mg/mL, clear, colorless
• storage temp.: 2-8°C
• SMILES string: CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)O[Ca]OC(=O)CCNC(=O)[C@H](O)C(C)(C)CO
• InChI: 1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1
• InChI key: FAPWYRCQGJNNSJ-UBKPKTQASA-L

Description

General description

Plants and microorganisms, such as Escherichia coli are the major sources of D-pantothenic acid. It is water soluble and quite stable to heating.

Application

D-Pantothenic acid hemicalcium salt has been used:

• as a component of FMX-turbodoma- derived media
• as a supplement in DMEM (Dulbecco′s modified eagle media)/F-12 used for cell proliferation
• as a supplement in preadipocyte media

Precursor in the biosynthesis of coenzyme A.

Biochem/physiol Actions

Along with coenzyme A (CoA, D-pantothenic acid is a precursor for acyl carrier protein. These are essential cofactors involved in fat, protein and carbohydrate metabolism. It also participates in the formation of acetylcholine neurotransmitter. D-pantothenic acid is considered as a source of nutrition and possesses immune function by mediating antibody formation. The production of cortisone is supported by D-pantothenic acid. It is essential for adrenal gland activity.

Physical properties

Due to the unstable, hygroscopic nature of the free acid, the calcium salt is employed.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves