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MAK123

Sigma-Aldrich

α-Glucosidase Activity Assay Kit

sufficient for 100 colorimetric tests

Synonym(s):

α-Glucosidase Test Kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84

usage

sufficient for 100 colorimetric tests

detection method

colorimetric

relevant disease(s)

endocrinological disorders, diabetes; neurological disorders

storage temp.

−20°C

Gene Information

human ... GAA(2548)
mouse ... GAA(14387)
rat ... GAA(367562)

General description

α-Glucosidase hydrolyzes carbohydrates by acting on terminal, non-reducing a(1→4)-linked D-glucose residues with the release of D-glucose. Defects in α-glucosidase have been implicated in Pompe disease and diabetes.

Application

α-Glucosidase Activity Assay Kit has been used to measure the activity of a-glucosidase.

Features and Benefits

Compatible with high-throughput handling systems.

Suitability

Suitable for the detection of α-glucosidase activity in biological samples.

Principle

In this assay,α-glucosidase activity is determined by a reaction in which α-glucosidase hydrolyzes p-nitrophenyl-α-D-glucopyranoside resulting in the formation of a colorimetric (405 nm) product, proportional to the α-glucosidase activity present

Storage Class Code

10 - Combustible liquids


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Inhibitory effect of rhubarb on intestinal a-glucosidase activity in type 1 diabetic rats.
Hou K J, et al.
Tropical Journal of Pharmaceutical Research, 16(6), 1293-1297 (2017)
Youngse Oh et al.
Molecules (Basel, Switzerland), 26(2) (2021-01-16)
Catalpa pod has been used in traditional medicine for the treatment of diabetes mellitus in South America. Studies on the constituents of Catalpa species have shown that it is rich in iridoids. In the present study, three previously undescribed compounds
Structure of human lysosomal acid a-glucosidase?a guide for the treatment of Pompe disease.
Veronique R Z, et al.
Nature Communications, 8(1), 1111-1111 (2017)
Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster.
Wagner A E, et al.
Oncotarget, 6(31), 30568-30568 (2015)
Anika E Wagner et al.
Oncotarget, 6(31), 30568-30578 (2015-09-17)
In this study, we tested whether a standardized epigallocatechin-3-gallate (EGCG) rich green tea extract (comprising > 90% EGCG) affects fitness and lifespan as well as parameters of glucose metabolism and energy homeostasis in the fruit fly, Drosophila melanogaster. Following the

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