Skip to Content
Merck
  • HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.

HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.

Nature communications (2017-10-17)
Jie Zheng, Mi Ra Chang, Ryan E Stites, Yong Wang, John B Bruning, Bruce D Pascal, Scott J Novick, Ruben D Garcia-Ordonez, Keith R Stayrook, Michael J Chalmers, Jeffrey A Dodge, Patrick R Griffin
PMID29030554
ABSTRACT

The vitamin D receptor/retinoid X receptor-α heterodimer (VDRRXRα) regulates bone mineralization via transcriptional control of osteocalcin (BGLAP) gene and is the receptor for 1α,25-dihydroxyvitamin D