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Independent hypothalamic circuits for social and predator fear.

Nature neuroscience (2013-11-12)
Bianca A Silva, Camilla Mattucci, Piotr Krzywkowski, Emanuele Murana, Anna Illarionova, Valery Grinevich, Newton S Canteras, Davide Ragozzino, Cornelius T Gross
ABSTRACT

The neural circuits mediating fear to naturalistic threats are poorly understood. We found that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region that has been implicated in feeding, sex and aggression, are essential for predator and social fear in mice. Our results establish a critical role for VMH in fear and have implications for selective intervention in pathological fear in humans.

MATERIALS
Product Number
Brand
Product Description

Clozapine, European Pharmacopoeia (EP) Reference Standard
Clozapine for peak identification, European Pharmacopoeia (EP) Reference Standard