- Total synthesis of ascididemin via anionic cascade ring closure.
Total synthesis of ascididemin via anionic cascade ring closure.
Chemical communications (Cambridge, England) (2012-08-07)
Ida Nymann Petersen, François Crestey, Jesper Langgaard Kristensen
PMID22864261
ABSTRACT
A new and convergent synthesis of ascididemin is presented. Using an anionic cascade ring closure as the key step, this natural product is obtained in 45% overall yield in just 6 steps starting from 2'-fluoroacetophenone. This new approach was extended to the synthesis of a new isomer of ascididemin.