Skip to Content
Merck
  • Transamidation of primary amides with amines catalyzed by zirconocene dichloride.

Transamidation of primary amides with amines catalyzed by zirconocene dichloride.

Chemical communications (Cambridge, England) (2012-10-26)
Benjamin N Atkinson, A Rosie Chhatwal, Helen V Lomax, James W Walton, Jonathan M J Williams
PMID23097018
ABSTRACT

Zirconocene dichloride (Cp(2)ZrCl(2)) has been shown to be an effective catalyst for the transamidation of primary amides with amines in cyclohexane at 80 °C in 5-24 hours. For favourable substrates, the reaction can be performed at temperatures as low as 30 °C.