- Synthesis and biological activity of modified thiopyrimidine nucleosides.
Synthesis and biological activity of modified thiopyrimidine nucleosides.
Nucleosides & nucleotides (2000-01-05)
A M Attia, M A Sallam, A A Almehdi, M M Abbasi
PMID10616732
ABSTRACT
N3-beta-D-glucopyranosyl, galactopyranosyl and xylopyranosyl 6-methyl-2-methylthiouracil and their 5-bromo derivatives have been synthesized by coupling an alpha-acetobromosugar with the corresponding thiouracil. The new modified thiouridine analogues were evaluated for their inhibitory activity against Human Immunodeficiency Virus (HIV) replication in MT-4 cells as well as for their cytotoxicity.
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