- Fungicidal activity of truncated analogues of dihydrosphingosine.
Fungicidal activity of truncated analogues of dihydrosphingosine.
Bioorganic & medicinal chemistry letters (2008-06-06)
Karin Thevissen, Ulrik Hillaert, Els M K Meert, Kuen K Chow, Bruno P A Cammue, Serge Van Calenbergh, Isabelle E J A François
PMID18524581
ABSTRACT
The minimal fungicidal concentration (MFC) of dihydrosphingosine (DHS), phytosphingosine (PHS), and five short-chain DHS derivatives was determined for Candida albicans and Candida glabrata. In this respect, a C15- and a C17-homologue of DHS showed a 2- to 10-fold decreased MFC as compared to native DHS (i.e. C18-DHS). DHS derivatives that were active, that is, comprising 12, 15, 17, or 18 carbon atoms, induced accumulation of reactive oxygen species (ROS) in C. albicans.