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SML3521

Sigma-Aldrich

m-Trifluoromethyl-diphenyl diselenide

≥98% (HPLC)

Synonym(s):

1,2-Bis(3-(trifluoromethyl)phenyl)diselane, Bis(3-trifluoromethylphenyl) diselenide, Di(3-trifluoromethylphenyl) diselenide, TFDD, [(m-CF3-PhSe)2; Bis[3-(trifluoromethyl)phenyl] diselenide

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About This Item

Empirical Formula (Hill Notation):
C14H8F6Se2
CAS Number:
53973-75-4
Molecular Weight:
448.12
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.25

Quality Level

100

Assay

≥98% (HPLC)

form

oil

color

colorless to yellow

storage temp.

-10 to -25°C

SMILES string

FC(F)(C1=CC([Se][Se]C2=CC=CC(C(F)(F)F)=C2)=CC=C1)F

Biochem/physiol Actions

m-Trifluoromethyl-diphenyl diselenide (TFDD) is a brain blood barrier penetrant organoselenium compound that exhibits antinociceptive and antidepressant effects in animal models without development of tolerance or withdrawal sighs. m-Trifluoromethyl-diphenyl diselenide acts as opioid system modulator, which attenuates morphine withdrawal signs in mice. It exhibits antioxidant and anti-inflammatory properties which might contribute to neuro protective effects.

Signal Word

Danger

Hazard Statements

H301 + H331,H373,H410

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cleisson Schossler Garcia et al.
Molecular neurobiology, 58(10), 5078-5089 (2021-07-11)
Chronic pain and depression often coexist sharing common pathological mechanisms, and available analgesics and antidepressants have demonstrated limited clinical efficacy. Evidence has demonstrated that neuronal oxidative stress, apoptosis, and also glucocorticoid receptor dysregulation facilitate the occurrence and development of both
Contribution of Opioid and Nitrergic Systems to m-Trifluoromethyl diphenyl Diselenide Attenuates Morphine-Induced Tolerance in Mice
ACS Chemical Neuroscience, 13(7), 910-919 (2022)
Carolina C Martins et al.
Progress in neuro-psychopharmacology & biological psychiatry, 98, 109803-109803 (2019-11-07)
The opioid withdrawal syndrome is defined as a complex phenomenon involving multiple cellular adaptations, which leads to the emergence of aversive physical and affective signs. The m-trifluoromethyl-diphenyl diselenide (m-CF3-PhSe)2 elicits an antidepressant-like effect by modulating the opioid system in different

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