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Merck

TRPV4

transient receptor potential cation channel, subfamily V, member 4

Synonyms:
CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
Species:
UniProtKB ID:
Gene ID:
  • Human(59341) Summary: This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
  • Mouse(63873) transient receptor potential cation channel, subfamily V, member 4
  • Rat(66026) transient receptor potential cation channel, subfamily V, member 4
  • naked mole-rat(101706710) transient receptor potential cation channel, subfamily V, member 4
  • domestic guinea pig(100724607) transient receptor potential cation channel, subfamily V, member 4
  • sheep(101113534) transient receptor potential cation channel, subfamily V, member 4
  • domestic cat(101084907) transient receptor potential cation channel, subfamily V, member 4
  • Horse(100066552) transient receptor potential cation channel, subfamily V, member 4
  • cow(540259) transient receptor potential cation channel, subfamily V, member 4
  • chicken(395427) transient receptor potential cation channel, subfamily V, member 4
  • dog(486308) transient receptor potential cation channel, subfamily V, member 4
  • Zebrafish(557850) transient receptor potential cation channel, subfamily V, member 4

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Small Molecule - Agonist

Product Number
Description
Species
Dihydrocapsaicin, from Capsicum sp., ≥85%,
Species
rat, human
N-Vanillylnonanamide, ≥97%, powder,
Species
rat

Small Molecule - Antagonist

Product Number
Description
Species
Capsazepine, ≥98% (HPLC), solid,
Species
human, rat
Capsaicin, natural,
Species
rat, human
Capsaicin, ≥95%, from Capsicum sp.,
Species
rat, human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Species
rat, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Species
human, rat, mouse

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-TRPV4 Antibody, clone 1G10-L2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
canine, human, mouse, rat
Application
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, rabbit
Application
immunohistochemistry
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, rabbit
Application
immunohistochemistry
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Species Reactivity
rat
Application
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Butamben, United States Pharmacopeia (USP) Reference Standard,
Species
human
Capsaicin, natural,
Species
rat, human
Capsaicin, ≥95%, from Capsicum sp.,
Species
rat, human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Species
rat, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Species
human, rat, mouse

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
N-Vanillylnonanamide, ≥97%, powder,
Species
rat
Capsazepine, ≥98% (HPLC), solid,
Species
human, rat

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Trpv4,
Species
mouse
MISSION® esiRNA, targeting human TRPV4,
Species
human