PRKAR2A
protein kinase, cAMP-dependent, regulatory, type II, alpha
Synonyms:
PKR2, PRKAR2
Species:
Human PRKAR2A (5576), Mouse Prkar2a (19087), Rat Prkar2a (29699), sheep PRKAR2A (101118483), naked mole-rat Prkar2a (101706516), cow PRKAR2A (518399), dog PRKAR2A (100685147), cow PRKAR2A (100139910), domestic guinea pig Prkar2a (100728915)
UniProtKB ID:
Gene ID:
- Human(5576) Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
- Mouse(19087) protein kinase, cAMP dependent regulatory, type II alpha
- Rat(29699) protein kinase, cAMP dependent regulatory, type II alpha
- sheep(101118483) protein kinase, cAMP-dependent, regulatory, type II, alpha
- naked mole-rat(101706516) protein kinase, cAMP-dependent, regulatory, type II, alpha
- cow(518399) protein kinase, cAMP-dependent, regulatory, type II, alpha
- dog(100685147) protein kinase, cAMP-dependent, regulatory, type II, alpha
- cow(100139910) protein kinase, cAMP-dependent, regulatory, type II, alpha
- domestic guinea pig(100728915) protein kinase, cAMP-dependent, regulatory, type II, alpha
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-PRKAR2A, (N-terminal) antibody produced in mouse, clone 3C7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-PRKAR2A antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-PRKAR2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-Phospho-PKA RIIα (PRKAR2A)-S99 antibody produced in rabbit, ,
Species Reactivity
human
Application
western blot
Anti-PKA RIIα (PRKAR2A) Antibody, clone 9C6B3, Rabbit Monoclonal, ,
Species Reactivity
human
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt, ≥97.0% (HPLC), powder,
Species
human