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Merck

MMP8

matrix metallopeptidase 8 (neutrophil collagenase)

Synonyms:
CLG1, HNC, MMP-8, PMNL-CL
Species:
UniProtKB ID:
Gene ID:
  • Human(4317) Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
  • Mouse(17394) matrix metallopeptidase 8
  • Rat(63849) matrix metallopeptidase 8
  • domestic guinea pig(100724670) matrix metallopeptidase 8 (neutrophil collagenase)
  • naked mole-rat(101716969) matrix metallopeptidase 8 (neutrophil collagenase)
  • sheep(101120601) matrix metallopeptidase 8 (neutrophil collagenase)
  • domestic cat(101080995) matrix metallopeptidase 8 (neutrophil collagenase)
  • Horse(100069005) matrix metallopeptidase 8 (neutrophil collagenase)
  • cow(100336575) matrix metallopeptidase 8 (neutrophil collagenase)
  • dog(489429) matrix metallopeptidase 8 (neutrophil collagenase)

Custom & Knockdown Gene Products

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ELISA

Product Number
Description
Species
Human MMP-8 ELISA Kit, for serum, plasma, conditioned medium, urine,
Species
human
Rat MMP-8 ELISA Kit, for serum, plasma, cell culture supernatant,
Species
mouse

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-MMP8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
Species Reactivity
human
Application
immunohistochemistry
Anti-MMP8 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Species Reactivity
human
Application
immunohistochemistry
Anti-Mmp8 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence

Small Molecule - Inhibitor

Product Number
Description
Species
Doxycycline Monohydrate, United States Pharmacopeia (USP) Reference Standard,
Species
human
α-Sexithiophene, ,
Species
human, rat
PD166793 hydrate, ≥98% (HPLC),
Species
human, rat, mouse
CP-101537, ≥98% (HPLC),
Species
human, rat, mouse
CP-471474, ≥98% (HPLC),
Species
human, rat, mouse

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MMP8,
Species
human