DNASE1
deoxyribonuclease I
Synonyms:
DNL1, DRNI
Species:
Human DNASE1 (1773), Mouse Dnase1 (13419), Rat Dnase1 (25633), naked mole-rat Dnase1 (101713435), domestic guinea pig Dnase1 (100718441), sheep DNASE1 (101122154), Horse DNASE1 (100034219), cow DNASE1 (282217), Domestic Rabbit DNASE1 (100009513), dog DNASE1 (403413) ...More
UniProtKB ID:
Gene ID:
- Human(1773) Summary: This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
- Mouse(13419) deoxyribonuclease I
- Rat(25633) deoxyribonuclease I
- naked mole-rat(101713435) deoxyribonuclease I
- domestic guinea pig(100718441) deoxyribonuclease I
- sheep(101122154) deoxyribonuclease I
- Horse(100034219) deoxyribonuclease I
- cow(282217) deoxyribonuclease I
- Domestic Rabbit(100009513) deoxyribonuclease I
- dog(403413) deoxyribonuclease I
- domestic cat(101096195) deoxyribonuclease I
- chicken(395725) deoxyribonuclease I
- Zebrafish(436947) deoxyribonuclease I
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-DNASE1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-DNASE1 (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, human, rat
Application
western blot
Anti-DNASE1 (N-terminal) antibody produced in rabbit FITC conjugated, affinity isolated antibody,
Species Reactivity
bovine, human, rat
Application
Anti-DNASE1 (N-terminal) antibody produced in rabbit HRP conjugated, affinity isolated antibody,
Species Reactivity
bovine, human, rat
Application
Proteins
Product Number
Description
Species
DNase I recombinant, grade I, from bovine pancreas, expressed in Pichia pastoris,
Species
cow
Deoxyribonuclease I from bovine pancreas, Type II, lyophilized powder, Protein ≥80 %, ≥2,000 units/mg protein,
Species
Deoxyribonuclease I from bovine pancreas, Standardized vial containing 2,000 Kunitz units of DNase I (D4527), vial of ≥0.25 mg total protein,
Species
Deoxyribonuclease I from bovine pancreas, Type IV, lyophilized powder, ≥2,000 Kunitz units/mg protein,
Species