Primary Human Hepatocytes for In Vitro Testing

Human Hepatocytes are valuable and instrumental for in vitro testing. They have become the “gold standard” for metabolism, clearance, hepatotoxicity, and drug-drug interaction.

In order to best meet the specific needs of a wide variety of study types, we offer different hepatocyte products derived from human liver tissue. Our wide selection of lots that can be used for a variety of applications, including, but not
limited to:

• Drug metabolism studies including stability, clearance, and species comparison
• Induction and toxicity studies
• Drug transporter assays (uptake and efflux)

Figure 1. Day 5 image of a selected lot of cryoplateable primary human hepatocytes at 10X magnification.

Each batch of hepatocytes are characterized with batch-specific functionality and clinical data to best permit lot selections and reservations:

• Cell viability and yield per vial
• Morphological integrity and attachment efficiency
• Monolayer confluency
• Phase I and phase II drug metabolizing enzyme activities
• CYP induction when applicable
• Additional functional testing can be performed upon request for specific cell culture applications
• A comprehensive Certificate of Analysis (CoA) with relevant donor demographics, BMI, pre-mortem liver function lab values, and medical history

Click here to get a complete list of currently available hepatocyte lots from LifeNet Health^®.

LifeNet Health Primary Human Hepatocytes