- Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate.
Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate.
Free radical biology & medicine (2017-09-03)
Shilpy Dixit, Joshua P Fessel, Fiona E Harrison
PMID28863942
RESUMEN
Mitochondrial dysfunction is elevated in very early stages of Alzheimer's disease and exacerbates oxidative stress, which contributes to disease pathology. Mitochondria were isolated from 4-month-old wild-type mice, transgenic mice carrying the APP
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Tetramethylrhodamine ethyl ester perchlorate, suitable for fluorescence, ≥90% (HPCE)