Differential Effect of Wortmannolone Derivatives on MDA-MB-231 Breast Cancer Cells.

The survival rate of women diagnosed with triple-negative breast-cancer (TNBC) remains low. Hence, this study aimed at the chemical and biological optimization of furanosteroid derivatives for the treatment of this type of malignancy using TNBC cells. Semi-synthetic analogs of wortmannolone ( Wortmannolone derivatization generated NF-ĸB inhibitors as new lead structures for further development. Compound ( Structure-activity analysis in the present study showed that acetylation of the hydroxyl groups and substitution on C3 and C17 of wortmannolone enhanced biological activity. Alpha-substitution of the acetyl group in C3 on ring A (compound