Saltar al contenido

Fechas de fin de año: Facturación de pedidos para envío en Ciudad de México, zona Metropolitana del Valle de México y Toluca hasta 13/12. Para otras regiones, hasta el 11/12. Receso de Merck Mexico del 18/12 al 02/01.

Merck

Coop functions as a corepressor of Pangolin and antagonizes Wingless signaling.

Genes & development (2010-05-05)
Haiyun Song, Sandra Goetze, Johannes Bischof, Chloe Spichiger-Haeusermann, Marco Kuster, Erich Brunner, Konrad Basler
RESUMEN

Wingless (Wg) signaling regulates expression of its target genes via Pangolin and Armadillo, and their interacting cofactors. In the absence of Wg, Pangolin mediates transcriptional repression. In the presence of Wg, Pangolin, Armadillo, and a cohort of coactivators mediate transcriptional activation. Here we uncover Coop (corepressor of Pan) as a Pangolin-interacting protein. Coop and Pangolin form a complex on DNA containing a Pangolin/TCF-binding motif. Overexpression of Coop specifically represses Wg target genes, while loss of Coop function causes derepression. Finally, we show that Coop antagonizes the binding of Armadillo to Pangolin, providing a mechanism for Coop-mediated repression of Wg target gene transcription.