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The role of iron in brain ageing and neurodegenerative disorders.

The role of iron in brain ageing and neurodegenerative disorders.

The Lancet. Neurology (2014-09-19)

Roberta J Ward, Fabio A Zucca, Jeff H Duyn, Robert R Crichton, Luigi Zecca

RESUMEN

In the CNS, iron in several proteins is involved in many important processes such as oxygen transportation, oxidative phosphorylation, myelin production, and the synthesis and metabolism of neurotransmitters. Abnormal iron homoeostasis can induce cellular damage through hydroxyl radical production, which can cause the oxidation and modification of lipids, proteins, carbohydrates, and DNA. During ageing, different iron complexes accumulate in brain regions associated with motor and cognitive impairment. In various neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, changes in iron homoeostasis result in altered cellular iron distribution and accumulation. MRI can often identify these changes, thus providing a potential diagnostic biomarker of neurodegenerative diseases. An important avenue to reduce iron accumulation is the use of iron chelators that are able to cross the blood-brain barrier, penetrate cells, and reduce excessive iron accumulation, thereby affording neuroprotection.

MATERIALES

Referencia del producto

Marca

Descripción del producto

Sigma-Aldrich

Iron, ≥99%, reduced, powder (fine)

Sigma-Aldrich

Carbonyl iron, ≥97% Fe basis

Sigma-Aldrich

Iron, puriss. p.a., carbonyl-Iron powder, low in magnesium and manganese compounds, ≥99.5% (RT)

Sigma-Aldrich

Iron, powder, −325 mesh, 97%

Sigma-Aldrich

Iron, granular, 10-40 mesh, >99.99% trace metals basis

Sigma-Aldrich

Iron, chips, 99.98% trace metals basis

Sigma-Aldrich

Iron, wire, diam. 1.0 mm, ≥99.9% trace metals basis

Iron, foil, 100x100mm, thickness 0.25mm, hard, 99.5%

Sigma-Aldrich

Iron, foil, thickness 0.25 mm, ≥99.99% trace metals basis

Iron, foil, 300x300mm, thickness 0.1mm, hard, 99.5%

Iron, foil, 100x100mm, thickness 0.125mm, as rolled, 99.99+%

Iron, rod, 200mm, diameter 25mm, as drawn, 98+%

Iron, tube, 200mm, outside diameter 8.0mm, inside diameter 5mm, wall thickness 1.5mm, annealed, 99.5%

Iron, rod, 100mm, diameter 100mm, as drawn, armcO« soft ingot 99.8%

Iron, foil, 100x100mm, thickness 1.0mm, as rolled, 99.5%

Iron, rod, 50mm, diameter 5.0mm, as drawn, 99.99+%

Iron, foil, 100x100mm, thickness 0.5mm, hard, 99.5%

Iron, foil, 150x150mm, thickness 1.5mm, as rolled, 99.5%

Iron, rod, 150mm, diameter 6.0mm, as drawn, 99.99+%

Iron, rod, 100mm, diameter 2.0mm, as drawn, 99.95%

Iron, foil, 25x25mm, thickness 0.9mm, as rolled, 99.5%

Iron, tube, 200mm, outside diameter 5.0mm, inside diameter 4.5mm, wall thickness 0.25mm, as drawn, 99.5%

Iron, foil, 25x25mm, thickness 1.0mm, as rolled, 99.5%

Iron, foil, 50x50mm, thickness 0.1mm, hard, 99.5%

Iron, rod, 200mm, diameter 9.5mm, as drawn, soft ingot 99.8+%

Iron, rod, 500mm, diameter 4.8mm, as drawn, 98+%

Iron, foil, 25x25mm, thickness 0.5mm, hard, 99.5%

Iron, rod, 200mm, diameter 6.35mm, as drawn, soft ingot 99.8%

Iron, foil, 300x300mm, thickness 0.125mm, hard, 99.5%

Iron, rod, 1000mm, diameter 19mm, as drawn, soft ingot 99.8%