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Fechas de fin de año: Facturación de pedidos para envío en Ciudad de México, zona Metropolitana del Valle de México y Toluca hasta 13/12. Para otras regiones, hasta el 11/12. Receso de Merck Mexico del 18/12 al 02/01.

Merck
  • Comparison of diagnostic accuracy of combined assessment using adenosine stress computed tomography perfusion + computed tomography angiography with transluminal attenuation gradient + computed tomography angiography against invasive fractional flow reserve.

Comparison of diagnostic accuracy of combined assessment using adenosine stress computed tomography perfusion + computed tomography angiography with transluminal attenuation gradient + computed tomography angiography against invasive fractional flow reserve.

Journal of the American College of Cardiology (2014-03-25)
Dennis T L Wong, Brian S Ko, James D Cameron, Darryl P Leong, Michael C H Leung, Yuvaraj Malaiapan, Nitesh Nerlekar, Marcus Crossett, John Troupis, Ian T Meredith, Sujith K Seneviratne
RESUMEN

The goal of this study was to compare the diagnostic accuracy of combined computed tomography perfusion (CTP) + computed tomography angiography (CTA), transluminal attenuation gradient by 320-detector row computed tomography (TAG320) + CTA, and CTP + TAG320 + CTA (multidetector computed tomography-integrated protocol [MDCT-IP]) assessment in predicting significant fractional flow reserve (FFR). CTA has limited specificity for predicting functionally significant stenoses. Novel CT techniques, including adenosine stress CTP and TAG320, may improve the diagnostic accuracy of CTA. CTA, CTP, and TAG320 were assessed using 320-detector row MDCT. Patients who underwent CTA, CTP, and FFR assessment on invasive coronary angiography were included. CTP was assessed using the visual perfusion assessment. TAG320 was defined as the linear regression coefficient between luminal attenuation and axial distance. A TAG320 cutoff value of -15.1 HU/10 mm as previously described was defined as significant. Functionally significant coronary stenosis was defined as FFR ≤0.8. The cohort included 75 patients (age 64.1 ± 10.8 years, 52 men) and 44 (35%) FFR-significant vessels. In 127 vessels, CTA predicted FFR-significant stenosis with 89% sensitivity and 65% specificity compared with MDCT-IP, which showed 88% sensitivity and 83% specificity. In 97 vessels in which the results of all techniques were available, TAG320 + CTA (area under the curve [AUC] = 0.844) and CTP + CTA (AUC = 0.845) had comparable per-vessel diagnostic accuracy (p = 0.98). The diagnostic accuracy of MDCT-IP (AUC = 0.91) was superior to TAG320 + CTA or CTP + CTA (p = 0.01). In vessels without significant calcification or artefact, TAG320 + CTA and CTP + CTA provide comparable diagnostic accuracy for functional assessment of coronary artery stenosis. MDCT-IP may provide the best diagnostic accuracy for functional assessment of coronary artery stenosis.

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Adenosine, ≥99%
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Adenosine, suitable for cell culture, BioReagent
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5 g
1 Disponible para envío el 02 de enero de 2025
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MXP 895.00
25 g
1 Fecha estimada de envío 22 de febrero de 2025
MXP 2,990.00
Sigma-Aldrich
Adenosine
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Supelco
Adenosine, Pharmaceutical Secondary Standard; Certified Reference Material
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Adenosine, European Pharmacopoeia (EP) Reference Standard
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