Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI.

Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI.

Nanoscale (2011-11-09)

Ruijun Xing, Fan Zhang, Jin Xie, Maria Aronova, Guofeng Zhang, Ning Guo, Xinglu Huang, Xiaolian Sun, Gang Liu, L Henry Bryant, Ashwinkumar Bhirde, Amy Liang, Yanglong Hou, Richard D Leapman, Shouheng Sun, Xiaoyuan Chen

PMID22064945

RESUMEN

We report in this communication a simple, facile surface modification strategy to transfer hydrophobic manganese oxide nanoparticles (MONPs) into water by using polyaspartic acid (PASP). We systematically investigated the effect of the size of PASP-MONPs on MRI of normal liver and found that the particles with a core size of 10 nm exhibited greater enhancement than those with larger core sizes.