- An approach to the skeleton of the securinega alkaloids. The total synthesis of (+/-)-securinine.
An approach to the skeleton of the securinega alkaloids. The total synthesis of (+/-)-securinine.
Organic letters (2001-03-22)
S Liras, J E Davoren, J Bordner
PMID11259041
RESUMEN
[structure: see text]. The concise total synthesis of securinine in nine steps from readily available starting materials is described. Key steps of the synthesis include an addition of a silyloxyfuran to an in situ generated iminium ion and a novel ring closing metathesis reaction.
MATERIALES