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Merck

An approach to the skeleton of the securinega alkaloids. The total synthesis of (+/-)-securinine.

Organic letters (2001-03-22)
S Liras, J E Davoren, J Bordner
RESUMEN

[structure: see text]. The concise total synthesis of securinine in nine steps from readily available starting materials is described. Key steps of the synthesis include an addition of a silyloxyfuran to an in situ generated iminium ion and a novel ring closing metathesis reaction.

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Sigma-Aldrich
Securinine, ≥98% (HPLC)