Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors.

Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors.

Bioorganic & medicinal chemistry (2013-09-28)

Tzung-Sheng Lin, Ya-Wen Liw, Jen-Shin Song, Tsung-Chih Hsieh, Hsien-Wei Yeh, Lih-Ching Hsu, Chun-Jung Lin, Szu-Huei Wu, Pi-Hui Liang

PMID24071445

RESUMEN

Novel C-aryl-d-glucofuranosides were synthesized and evaluated for their capacity to inhibit human sodium-dependent glucose co-transporter 2 (hSGLT2) and hSGLT1. Compound 21q demonstrated the best in vitro inhibitory activity against SGLT2 in this series (EC50=0.62μM).