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Key Documents

SRP0322

Sigma-Aldrich

JMJD6 human

recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

Sinónimos:

Jumonji domain-containing protein 6, PSR, PTDSR

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥80% (SDS-PAGE)

form

aqueous solution

mol wt

74 kDa

packaging

pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

1.87 mg/mL

NCBI accession no.

NM_001081461

UniProt accession no.

Q6NYC1

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... JMJD6(23210)

General description

Human JMJD6 (Jumonji domain containing 6), also known as PTDSR (GenBank Accession No. NM_001081461), amino-acids 2-414 (end) with an N-terminal GST-tag, MW=74 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Phillip Hahn et al.
PloS one, 5(10), e13769-e13769 (2010-11-10)
Methylation of residues in histone tails is part of a network that regulates gene expression. JmjC domain containing proteins catalyze the oxidative removal of methyl groups on histone lysine residues. Here, we report studies to test the involvement of Jumonji
Bingsheng Chang et al.
Science (New York, N.Y.), 318(5849), 444-447 (2007-10-20)
Arginine methylation occurs on a number of proteins involved in a variety of cellular functions. Histone tails are known to be mono- and dimethylated on multiple arginine residues where they influence chromatin remodeling and gene expression. To date, no enzyme
Abby Farrell et al.
JCI insight, 4(8) (2019-04-19)
Human placenta development and a successful pregnancy is incumbent upon precise oxygen-dependent control of trophoblast migration/invasion. Persistent low oxygen leading to failed trophoblast invasion promotes inadequate spiral artery remodeling, a characteristic of preeclampsia. Angiomotin (AMOT) is a multifaceted scaffolding protein
Yan Liu et al.
Oncogene, 38(7), 980-997 (2018-09-07)
Overexpression of Jumonji domain-containing 6 (JMJD6) has been reported to be associated with more aggressive breast cancer characteristics. However, the precise role of JMJD6 in breast cancer development remains unclear. Here, we demonstrate that JMJD6 has intrinsic tyrosine kinase activity
Celia J Webby et al.
Science (New York, N.Y.), 325(5936), 90-93 (2009-07-04)
The finding that the metazoan hypoxic response is regulated by oxygen-dependent posttranslational hydroxylations, which regulate the activity and lifetime of hypoxia-inducible factor (HIF), has raised the question of whether other hydroxylases are involved in the regulation of gene expression. We
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