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SML0439

Sigma-Aldrich

MBCQ

≥98% (HPLC)

Sinónimos:

4-((3,4-Methylenedioxybenzyl)amino)-6-chloroquinazoline

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About This Item

Fórmula empírica (notación de Hill):
C16H12ClN3O2
Número de CAS:
150450-53-6
Peso molecular:
313.74
MDL number:
MFCD00673946
UNSPSC Code:
41106305
PubChem Substance ID:
329824721
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

Clc1ccc2ncnc(NCc3ccc4OCOc4c3)c2c1

InChI

1S/C16H12ClN3O2/c17-11-2-3-13-12(6-11)16(20-8-19-13)18-7-10-1-4-14-15(5-10)22-9-21-14/h1-6,8H,7,9H2,(H,18,19,20)

InChI key

CNODHOSDWZLJGA-UHFFFAOYSA-N

Biochem/physiol Actions

MBCQ is selective inhibitor of cGMP-specific phosphodiesterase PDE V; IC50=19 nM.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Masashi Mukohda et al.
The Journal of clinical investigation, 129(6), 2318-2332 (2019-03-22)
Mice selectively expressing PPARγ dominant negative mutation in vascular smooth muscle exhibit RhoBTB1-deficiency and hypertension. Our rationale was to employ genetic complementation to uncover the mechanism of action of RhoBTB1 in vascular smooth muscle. Inducible smooth muscle-specific restoration of RhoBTB1
J F Heneghan et al.
American journal of physiology. Cell physiology, 309(5), C332-C347 (2015-06-26)
The potent trypanolytic properties of human apolipoprotein L1 (APOL1) can be neutralized by the trypanosome variant surface antigen gene product known as serum resistance-associated protein. However, two common APOL1 haplotypes present uniquely in individuals of West African ancestry each encode

Artículos

Phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. There are 11 different mammalian PDE families.

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

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