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H8885

Sigma-Aldrich

Hydroxyzine dihydrochloride

≥97%

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About This Item

Fórmula empírica (notación de Hill):
C21H27ClN2O2 · 2HCl
Número de CAS:
2192-20-3
Peso molecular:
447.83
EC Number:
218-586-3
MDL number:
MFCD00058200
UNSPSC Code:
12161501
PubChem Substance ID:
24895830
NACRES:
NA.77

assay

≥97%

form

powder

solubility

H2O: soluble
alcohol: soluble
chloroform: soluble

SMILES string

Cl[H].Cl[H].OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3

InChI

1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H

InChI key

ANOMHKZSQFYSBR-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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General description

Hydroxyzine dihydrochloride (HDH) is the first-generation antihistamine, that belongs to the piperazine class, an H1 receptor antagonist.

Application

Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.

Biochem/physiol Actions

Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sigma-Aldrich

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COMPARATIVE ANXIOLYTIC ACTIVITY OF VARIOUS DRUGS IN EXPERIMENTAL MODELS OF RATS
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Investigation into the characteristics of anesthetic interactions may provide clues to anesthesia mechanisms. Dexmedetomidine, an α(2)-adrenergic receptor agonist, has become a popular sedative in intensive care, and hydroxyzine, a histamine receptor antagonist, is well known as a tranquilizing premedication for
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Chromatograms

application for HPLC

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