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F6550

Sigma-Aldrich

Anti-FLIPα, C-Terminal antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Sinónimos:

Anti-CASH, Anti-CLARP, Anti-Casper, Anti-FLAME-1, Anti-I-FLICE

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About This Item

MDL number:
MFCD02096351
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 55 kDa

species reactivity

human

technique(s)

western blot: 0.5 μg/mL using human HeLa cell extract

UniProt accession no.

O15519

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CFLAR(8837)

Specificity

By immunoblotting, the antibody detects human FLIPα (FLICE-inhibitory protein).

Immunogen

synthetic peptide corresponding to amino acids 447-464 of human FLIPα/FLIPL.

Application

Anti-FLIPα, C-Terminal antibody is suitable for:
  • western blotting of whole L540 cell extracts to detect c-flip activity in the regulation of NF-κB distribution and activity by 5F11 and bortezomib
  • immunohistochemistry analysis to study the optimization of c-FLIP activity in lymphoma cells
  • immunohistochemical cytoplasmic c-Flip staining to detect c-FLIP expression in Burkitt′s lymphoma (BL) may be a reliable prognostic marker
  • western blot analysis at a concentration of 0.5μg/mL using human HeLa cell extract.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The fully human anti-CD30 antibody 5F11 activates NF-?B and sensitizes lymphoma cells to bortezomib-induced apoptosis.
Boris B et al.
Blood, 106(5) (2005)
Marie-Blanche Valnet-Rabier et al.
British journal of haematology, 128(6), 767-773 (2005-03-10)
The World Health Organization Classification of Lymphoid Neoplasms identifies Burkitt's lymphoma/leukaemia (BL) as a single entity, characterized by unique clinical and genetic features that require specific high intensity chemotherapy regimens. Although remarkable successes in the treatment of the disease have
I S van Houdt et al.
Histopathology, 51(6), 778-784 (2007-11-29)
Inhibition of apoptosis is important in the pathogenesis of lymphomas. c-FLIP, a regulator of caspase 8-mediated apoptosis, plays an important role in protecting normal B and T cells from apoptosis and possibly also in lymphomas. Because of contradictory reports about
Teruki Yanagi et al.
PloS one, 10(3), e0119404-e0119404 (2015-03-20)
While PCTAIRE1/PCTK1/Cdk16 is overexpressed in malignant cells and is crucial in tumorigenesis, its function in apoptosis remains unclear. Here we investigated the role of PCTAIRE1 in apoptosis, especially in the extrinsic cell death pathway. Gene-knockdown of PCTAIRE1 sensitized prostate cancer
Ines Müller et al.
Molecular cell, 77(5), 970-984 (2020-01-27)
Cytosolic caspase-8 is a mediator of death receptor signaling. While caspase-8 expression is lost in some tumors, it is increased in others, indicating a conditional pro-survival function of caspase-8 in cancer. Here, we show that tumor cells employ DNA-damage-induced nuclear

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