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Merck
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AV100774

Sigma-Aldrich

Anti-FOXK2 (AB2) antibody produced in rabbit

IgG fraction of antiserum

Sinónimos:

Anti-Forkhead box K2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

69 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

NP_004505

UniProt accession no.

Q01167

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FOXK2(3607)

General description

FOXK2 belongs to the mammalian forkhead transcription factor family and contains forkhead DNA-binding domain and an FHA domain at the N-terminal region.

Immunogen

Synthetic peptide directed towards the C terminal region of human FOXK2

Application

Anti-FOXK2 (AB2) antibody produced in rabbit is suitable for western blotting at a concentration of 2.5 μg/ml.

Biochem/physiol Actions

FOXK2 plays an important regulatory role in AP-1 binding and AP-1 mediated gene expression. It has been identified as regulator of IL-2 transcription and is linked to cell cycle progression. FOXK2 reportedly binds to DNA containing G/T mismatches with high affinity.

Sequence

Synthetic peptide located within the following region: SASLPTKRHNGDQPEQPELKRIKTEDGEGIVIALSVDTPPAAVREKGVQN

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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C Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(17), 7739-7743 (1991-09-01)
Human immunodeficiency virus (HIV) gene expression is regulated by both general transcription factors and factors induced by activation of T lymphocytes such as NF-kappa B and the nuclear factor of activated T cells (NFAT). Within the HIV long terminal repeat
Yoshito Fujii et al.
Journal of biochemistry, 147(5), 705-709 (2010-01-26)
DNA mismatch repair is an important mechanism in the prevention of mutations. We reported the existence in the HL60 cell line of a novel G/T-mismatch DNA-binding protein (nGTBP) requiring strict DNA sequences. In this report, we identify the FOXK2 transcription
Zongling Ji et al.
Molecular and cellular biology, 32(2), 385-398 (2011-11-16)
The transcriptional control circuitry in eukaryotic cells is complex and is orchestrated by combinatorially acting transcription factors. Forkhead transcription factors often function in concert with heterotypic transcription factors to specify distinct transcriptional programs. Here, we demonstrate that FOXK2 participates in
Anett Marais et al.
The Journal of biological chemistry, 285(46), 35728-35739 (2010-09-03)
Several mammalian forkhead transcription factors have been shown to impact on cell cycle regulation and are themselves linked to cell cycle control systems. Here we have investigated the little studied mammalian forkhead transcription factor FOXK2 and demonstrate that it is

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