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Key Documents

Certificado de origen (COO)/COA

A172

1-Aminocyclobutane-cis-1,3-dicarboxylic acid

Name: 1-Aminocyclobutane-<I>cis</I>-1,3-dicarboxylic acid
Brand: SIGMA

Sinónimos:

1-Amino-cis-1,3-cyclobutanedicarboxylic acid, cis-ACDA

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About This Item

UNSPSC Code:

12352200

solubility

0.1 M NaOH: 12 mg/mL
0.1 M HCl: 14 mg/mL
H₂O: 5.2 mg/mL
methanol: insoluble

Biochem/physiol Actions

Potent and selective NMDA receptor agonist

Other Notes

Note: Under IUPAC nomenclature, this compound is designated as trans

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids.

R D Allan et al.

Journal of medicinal chemistry, 33(10), 2905-2915 (1990-10-01)

We report the synthesis of a series of 3-carboxy-, 3-(carboxymethyl)-, 3-(omega-phosphonoalkyl)-1-aminocyclobutane-1-carboxylic acids for evaluation as agonists or antagonists of neurotransmission at excitatory amino acid receptors, particularly N-methyl-D-aspartic acid (NMDA) receptors. The compounds were evaluated as agonists on their ability to

The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.

Barbara Banelli et al.

Cell cycle (Georgetown, Tex.), 14(21), 3418-3429 (2015-11-15)

Notwithstanding current multimodal treatment, including surgery, radiotherapy and chemotherapy with temozolomide (TMZ), median survival of glioblastoma (GBM) patients is about 14 months, due to the rapid emergence of cell clones resistant to treatment. Therefore, understanding the mechanisms underlying chemoresistance is

Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1, and c-Jun N-terminal kinase-mediated pathway.

Yuri Chikano et al.

Molecular cancer therapeutics, 14(2), 564-574 (2014-12-17)

The failure of current treatment options for glioblastoma stems from their inability to control tumor cell proliferation and invasion. Biologically targeted therapies offer great hope and one promising target is glycogen synthase kinase-3β (GSK3β), implicated in various diseases, including cancer.

Lentivirus-mediated silencing of spindle and kinetochore-associated protein 1 inhibits the proliferation and invasion of neuronal glioblastoma cells.

Xiujuan Shi et al.

Molecular medicine reports, 11(5), 3533-3538 (2015-01-13)

Spindle and kinetochore‑associated protein 1 (SKA1) is an important component of the human kinetochore, which plays a key role in mitosis. The resent study was designed to investigate the role of SKA1 in human glioblastoma. The results of the present

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