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Merck
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Documentos

63493

Sigma-Aldrich

Hoechst 34580

Trihydrochloride salt, ≥98.0% (HPLC)

Sinónimos:

N,N-Dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5′-bi-1H-benzimidazol]-2′-yl]benzenamine trihydrochloride, HOE 34580

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About This Item

Fórmula empírica (notación de Hill):
C27H29N7 · 3HCl
Número de CAS:
911004-45-0
Peso molecular:
560.95
UNSPSC Code:
12352108
PubChem Substance ID:
329759866
NACRES:
NA.32

assay

≥98.0% (HPLC)

quality

Trihydrochloride salt

solubility

H2O: 1 mg/mL, clear, slightly yellow to deep greenish-yellow

fluorescence

λex 357 nm; λem 490 nm±10 nm in H2O (free dye)

storage temp.

−20°C

SMILES string

Cl.Cl.Cl.CN1CCN(CC1)c2ccc3nc([nH]c3c2)-c4ccc5nc([nH]c5c4)-c6ccc(cc6)N(C)C

InChI

1S/C27H29N7.3ClH/c1-32(2)20-7-4-18(5-8-20)26-28-22-10-6-19(16-24(22)30-26)27-29-23-11-9-21(17-25(23)31-27)34-14-12-33(3)13-15-34;;;/h4-11,16-17H,12-15H2,1-3H3,(H,28,30)(H,29,31);3*1H

InChI key

IPMZLKUUQSFUTA-UHFFFAOYSA-N

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Eveline A C Goossens et al.
International journal of molecular sciences, 21(10) (2020-05-21)
Myostatin is a negative regulator of muscle cell growth and proliferation. Furthermore, myostatin directly affects the expression of 14q32 microRNAs by binding the 14q32 locus. Direct inhibition of 14q32 microRNA miR-495-3p decreased postinterventional restenosis via inhibition of both vascular smooth
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Frontiers in cardiovascular medicine, 7, 604821-604821 (2021-02-16)
Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and immune modulation. We hypothesize that PCAF deficiency affects atherosclerosis via regulation of
Koos Rooijers et al.
Nature biotechnology, 37(7), 766-772 (2019-06-19)
Protein-DNA interactions are critical to the regulation of gene expression, but it remains challenging to define how cell-to-cell heterogeneity in protein-DNA binding influences gene expression variability. Here we report a method for the simultaneous quantification of protein-DNA contacts by combining
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