373277

Hh Signaling Antagonist XI, MRT-14

The Hh Signaling Antagonist XI, MRT-14 controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• Sinónimos: Hh Signaling Antagonist XI, MRT-14
• Fórmula empírica (notación de Hill): C₂₄H₂₃N₃O₆
• Número de CAS: 1192928-04-3
• Peso molecular: 449.46
• MDL number: MFCD32671861
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: O=C(NC(NC1=CC(NC(C2=CC=CC=C2)=O)=CC=C1)=O)C3=CC(OC)=C(C(OC)=C3)OC

Descripción

General description

A cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC₅₀ = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC₅₀ = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 & 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC₅₀ = 0.13 and 0.62 µM, respectively).

A cell-permeable acylurea compound that acts as an antagonistic Smo ligand (IC₅₀ = 120 nM against 5 nM Bodipy-cyclopamine binding to murine Smo-transfected HEK293 cells) and is more effective than Cyclopamine (Cat. No. 239803) in inhibiting ShhN-induced Gli transcription in Shh-light 2 cell assays (IC₅₀ = 0.16 and 0.3 µM, respectively) and in blocking 0.1 µM SAG- (Cat. Nos. 566660 and 566661) stimulated differentiation of C3H10T1/2 murine mesenchymal stem cells into osteoblasts (IC₅₀ = 0.13 and 0.62 µM, respectively).

The Hh Signaling Antagonist XI, MRT-14 controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Manetti, F., et al. 2010. Mol. Pharmacol.78, 658.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable