14-687-M

p38α/SAPK2a (T106M) Protein, active, 10 µg

Active, N-terminal GST-tagged, recombinant, human, full-length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 & repurified using glutathione-agarose. For use in Kinase Assays.

• UNSPSC Code: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Propiedades

• biological source: human
• Quality Level: 100; 300
• recombinant: expressed in E. coli
• mol wt: M_w 67.7 kDa
• manufacturer/tradename: Upstate^®
• technique(s): activity assay: suitable (kinase)
• NCBI accession no.: NM_001315.1; NM_139012.1; NM_139013.1; NM_139014.1
• UniProt accession no.: Q16539
• Gene Information: human ... MAPK14(1432)

Descripción

General description

N-terminal GST-tagged, recombinant, human, full-length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 (14-537) and repurified using glutathione- agarose.

Contains the gatekeeper mutation T160M in the ATP-binding domain. This mutation increases resistance to SB203580 as compared to the wild type sequence.

Product Source: Human, full-length p38α/SAPK2a containing the mutation T106M. Expressed in E. coli.

Quality

routinely evaluated by phosphorylation of MBP (13-104).

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2