D-070

N-Desmethylolanzapine-d₈ dihydrochloride solution

100 μg/mL in acetonitrile: water (1:1) (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Sinónimos: N-Desmethylolanzapine-D₈ dihydrochloride solution
• Fórmula empírica (notación de Hill): C₁₆D₈H₁₀N₄S · H₂Cl₂
• Peso molecular: 379.38
• UNSPSC Code: 41116107
• NACRES: NA.24

Propiedades

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in acetonitrile: water (1:1) (as free base)
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: 2-8°C

Descripción

General description

A stable-labeled internal standard for use in LC/MS or GC/MS applications including clinical toxicology analysis, therapeutic drug monitoring, or isotope dilution methods. Desmethylolanzapine is the primary metabolite of olanzapine, marketed as the atypical antipsychotic Zyprexa^® for the treatment of schizophrenia and bipolar disorder.

Application

• Monitoring Metabolic Parameters in Schizophrenia: A study utilized plasma levels of olanzapine and its metabolite, N-desmethyl-olanzapine, to monitor metabolic parameters in patients with schizophrenia, providing a critical link between antipsychotic drug concentrations and metabolic health. This research supports the use of these biomarkers in clinical settings to optimize therapeutic strategies and manage side effects (Lu et al., 2018).


• Evaluating Clinical Efficacy in Schizophrenia: Another significant study applied plasma levels of olanzapine and N-desmethyl-olanzapine to assess clinical efficacy in schizophrenia patients. By correlating drug levels with therapeutic outcomes, this approach aids in personalized medicine, ensuring patients receive optimal dosages for effective treatment (Lu et al., 2016).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Zyprexa is a registered trademark of Eli Lilly and Co.

Información de seguridad

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H302,H319
• pcodes: P210 - P233 - P240 - P241 - P301 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 55.4 °F - closed cup
• flash_point_c: 13 °C - closed cup