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Merck
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Documentos

69720

Sigma-Aldrich

1-Methylxanthine

≥97.0% (HPLC)

Sinónimos:

2,6-Dihydroxy-1-methylpurine

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About This Item

Fórmula empírica (notación de Hill):
C6H6N4O2
Número de CAS:
6136-37-4
Peso molecular:
166.14
Beilstein/REAXYS Number:
171507
EC Number:
228-108-5
MDL number:
MFCD00005561
UNSPSC Code:
12352100
PubChem Substance ID:
57652204
NACRES:
NA.22

assay

≥97.0% (HPLC)

form

powder

mp

≥300 °C

SMILES string

CN1C(=O)Nc2nc[nH]c2C1=O

InChI

1S/C6H6N4O2/c1-10-5(11)3-4(8-2-7-3)9-6(10)12/h2H,1H3,(H,7,8)(H,9,12)

InChI key

MVOYJPOZRLFTCP-UHFFFAOYSA-N

Gene Information

rat ... Adora1(29290) , Adora2a(25369)

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Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

related product

Referencia del producto
Descripción
Precios

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Seong-Yun Jeong et al.
International journal of pharmaceutics, 372(1-2), 132-139 (2009-01-27)
Most of methylxanthine derivatives including caffeine have been known to radiosensitize cancer cells, but the obstacles such as toxicity, request of high dose and poor solubility hinder their preclinical evaluations and clinical applications. In this study, we evaluated the efficacy
Catherine M Wheatley et al.
American journal of physiology. Endocrinology and metabolism, 287(4), E804-E809 (2004-06-24)
Exercise and insulin increase muscle glucose uptake by different mechanisms and also increase capillary recruitment, which is proposed to facilitate access for hormones and nutrients. The genetically obese Zucker rat shows impaired insulin- but not contraction-mediated glucose uptake in muscle.
Hyewon Youn et al.
International journal of radiation biology, 85(2), 167-174 (2009-03-13)
To determine the efficacy of a caffeine derivative 1-methylxanthine (1-MTX) in increasing radiosensitivity of cancer cells and elucidate the underlying mechanisms in vitro. RKO human colorectal cancer cells carrying wild type protein 53 kDa (p53) were incubated with 3 mM
Stephen Rattigan et al.
Exercise and sport sciences reviews, 33(1), 43-48 (2005-01-11)
Blood flow to contracting muscles is increased rapidly and is redistributed within the muscle. Recent research has highlighted that insulin causes similar changes, but these are absent in insulin resistance, resulting in impaired insulin-mediated muscle glucose uptake. Understanding the mechanisms
Hermann M Bolt et al.
Archives of toxicology, 79(4), 196-200 (2004-11-24)
A comparative study of N-acetyltransferase 2 (NAT2) genotyping and phenotyping (caffeine test method) was performed on 211 persons to elucidate apparent discrepancies in the assignment of NAT2*12 and NAT2*13 alleles which occur in the literature. The study used the standard
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