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Documentos

579602

Sigma-Aldrich

(R)-(+)-1,2-Dithiolane-3-pentanoic acid

97%

Sinónimos:

(R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid

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About This Item

Fórmula empírica (notación de Hill):
C8H14O2S2
Número de CAS:
1200-22-2
Peso molecular:
206.33
MDL number:
MFCD01631142
UNSPSC Code:
12352005
PubChem Substance ID:
24881001

assay

97%

form

solid

optical activity

[α]20/D +104°, c = 1 in chloroform

mp

48-52 °C (lit.)

SMILES string

OC(=O)CCCC[C@@H]1CCSS1

InChI

1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1

InChI key

AGBQKNBQESQNJD-SSDOTTSWSA-N

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

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Michela Rosini et al.
Journal of medicinal chemistry, 48(2), 360-363 (2005-01-22)
The coupling of two different pharmacophores, each endowed with different biological properties, afforded the hybrid compound lipocrine (7), whose biological profile was markedly improved relative to those of prototypes tacrine and lipoic acid. Lipocrine is the first compound that inhibits
Alessandra Antonello et al.
Journal of medicinal chemistry, 48(1), 28-31 (2005-01-07)
To combine in the same molecule alpha(1)-adrenoreceptor blocking and antioxidant properties, compounds 2-5 were designed and synthesized. All compounds were effective alpha(1)-adrenoreceptor antagonists and were tested in both functional and binding assays. In addition, compounds 2 and 5 also displayed
B Steinmann et al.
Helvetica paediatrica acta, 34(6), 589-599 (1979-01-01)
Strychnine, a potent antagonist of glycine was given to twins suffering from nonketotic hyperglycinemia at age 73 hours. Within hours of the onset of treatment favorable effects were observed such as improvements of muscle tone, movements, defense reactions, and probably
T Tankova et al.
International journal of clinical practice, 59(6), 645-650 (2005-06-01)
Twenty-three diabetic patients -- 16 men and seven women (mean age: 50.7 +/- 17.4 years; mean duration of diabetes: 13.6 +/- 6.9 years) -- with diabetic mononeuropathy of the cranial nerves participated in the study. Four of them were with
Daniel Konrad
Antioxidants & redox signaling, 7(7-8), 1032-1039 (2005-07-07)
Alpha-lipoic acid is a naturally occurring cofactor of mitochondrial dehydrogenase complexes and a potent antioxidant. It can interchange between a reduced form and an oxidized form, thereby displaying reducing (antioxidant) and prooxidant properties, respectively. It is suggested that alpha-lipoic acid
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