WRN
Werner syndrome, RecQ helicase-like
Sinónimos:
RECQ3, RECQL2, RECQL3
Especie:
Human WRN (7486), Mouse Wrn (22427), Rat Wrn (290806), naked mole-rat Wrn (101724469), domestic guinea pig Wrn (100719896), Domestic Rabbit WRN (100341925), sheep WRN (101106742), cow WRN (505061), domestic cat WRN (101095574), dog WRN (493997) ...Más
ID UniProtKB:
ID del gen:
- Human(7486) Summary: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]
- Mouse(22427) Werner syndrome homolog (human)
- Rat(290806) Werner syndrome
- naked mole-rat(101724469) Werner syndrome, RecQ helicase-like
- domestic guinea pig(100719896) Werner syndrome, RecQ helicase-like
- Domestic Rabbit(100341925) Werner syndrome, RecQ helicase-like
- sheep(101106742) Werner syndrome, RecQ helicase-like
- cow(505061) Werner syndrome, RecQ helicase-like
- domestic cat(101095574) Werner syndrome, RecQ helicase-like
- dog(493997) Werner syndrome, RecQ helicase-like
- chicken(422505) Werner syndrome
- Zebrafish(569495) Werner syndrome
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Monoclonal Anti-WRN antibody produced in mouse, clone 195C, purified from hybridoma cell culture,
Reactividad de especies
human
Aplicación
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-WRN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-Wrn Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-WRN Antibody, clone 20A11.1 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human
Aplicación
flow cytometry
immunocytochemistry
western blot
immunocytochemistry
western blot