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Merck

TRPV4

transient receptor potential cation channel, subfamily V, member 4

Sinónimos:
CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
Especie:
ID UniProtKB:
ID del gen:
  • Human(59341) Summary: This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
  • Mouse(63873) transient receptor potential cation channel, subfamily V, member 4
  • Rat(66026) transient receptor potential cation channel, subfamily V, member 4
  • naked mole-rat(101706710) transient receptor potential cation channel, subfamily V, member 4
  • domestic guinea pig(100724607) transient receptor potential cation channel, subfamily V, member 4
  • sheep(101113534) transient receptor potential cation channel, subfamily V, member 4
  • domestic cat(101084907) transient receptor potential cation channel, subfamily V, member 4
  • Horse(100066552) transient receptor potential cation channel, subfamily V, member 4
  • cow(540259) transient receptor potential cation channel, subfamily V, member 4
  • chicken(395427) transient receptor potential cation channel, subfamily V, member 4
  • dog(486308) transient receptor potential cation channel, subfamily V, member 4
  • Zebrafish(557850) transient receptor potential cation channel, subfamily V, member 4

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Small Molecule - Agonist

Referencia del producto
Descripción
Especie
Dihydrocapsaicin, from Capsicum sp., ≥85%,
Especie
rat, human

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
Capsazepine, ≥98% (HPLC), solid,
Especie
human, rat
Capsaicin, ≥95%, from Capsicum sp.,
Especie
rat, human
Capsaicin, natural,
Especie
rat, human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Especie
rat, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Especie
human, rat, mouse

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-TRPV4 Antibody, clone 1G10-L2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
canine, human, mouse, rat
Aplicación
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Reactividad de especies
rat
Aplicación
western blot
Anti-TRPV4 antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human
Aplicación
ELISA
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
Butamben, United States Pharmacopeia (USP) Reference Standard,
Especie
human
Capsaicin, ≥95%, from Capsicum sp.,
Especie
rat, human
Capsaicin, natural,
Especie
rat, human
Capsaicin, from Capsicum sp., ≥50% (HPLC),
Especie
rat, human
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Especie
human, rat, mouse

Small Molecule - Mixed Agonist/Antagonist

Referencia del producto
Descripción
Especie
Capsazepine, ≥98% (HPLC), solid,
Especie
human, rat

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting mouse Trpv4,
Especie
mouse
MISSION® esiRNA, targeting human TRPV4,
Especie
human