TBP
TATA box binding protein
Sinónimos:
GTF2D, GTF2D1, HDL4, SCA17, TFIID
Especie:
Human TBP (6908), Mouse Tbp (21374), Rat Tbp (117526), fruit fly Tbp (37476), Zebrafish tbp (368882), chicken TBP (395995), domestic cat TBP (101084200), dog TBP (611193), sheep TBP (100144760), cow TBP (516578) ...Más
ID UniProtKB:
ID del gen:
- Human(6908) Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
- Mouse(21374) TATA box binding protein
- Rat(117526) TATA box binding protein
- fruit fly(37476) TATA binding protein
- Zebrafish(368882) TATA box binding protein
- chicken(395995) TATA box binding protein
- domestic cat(101084200) TATA box binding protein
- dog(611193) TATA box binding protein
- sheep(100144760) TATA box binding protein
- cow(516578) TATA box binding protein
- domestic guinea pig(100733307) TATA box binding protein
- naked mole-rat(101702646) TATA box binding protein
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-TATA Binding Protein Antibody, clone 5J13, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse, rat
Aplicación
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-TBP antibody produced in rabbit, ,
Reactividad de especies
human
Aplicación
western blot
Anti-TBP antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot
western blot
Anti-TBP antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal Anti-TBP antibody produced in mouse, clone 58C9, purified from hybridoma cell culture,
Reactividad de especies
drosophila melanogaster, sf9 cell line, human, yeast
Aplicación
immunoprecipitation (IP)
western blot
western blot