SMAD4
SMAD family member 4
Sinónimos:
DPC4, JIP, MADH4, MYHRS
Especie:
Human SMAD4 (4089), Mouse Smad4 (17128), Rat Smad4 (50554), dog SMAD4 (476196), domestic cat SMAD4 (101093650), Zebrafish smad4 (30640), domestic guinea pig Smad4 (100717853), naked mole-rat Smad4 (101703764), sheep SMAD4 (443171), cow SMAD4 (540248) ...Más
ID UniProtKB:
ID del gen:
- Human(4089) Summary: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009]
- Mouse(17128) SMAD family member 4
- Rat(50554) SMAD family member 4
- dog(476196) SMAD family member 4
- domestic cat(101093650) SMAD family member 4
- Zebrafish(30640) MAD homolog 4 (Drosophila)
- domestic guinea pig(100717853) SMAD family member 4
- naked mole-rat(101703764) SMAD family member 4
- sheep(443171) SMAD family member 4
- cow(540248) SMAD family member 4
- Horse(100033846) SMAD family member 4
- Goat(100861019) SMAD family member 4
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ELISA
Referencia del producto
Descripción
Especie
Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-SMAD4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human, mouse
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-SMAD4 antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM277, purified immunoglobulin,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Monoclonal Anti-SMAD4 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL9774, purified immunoglobulin, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
[KO Validated]Anti-Smad4 Antibody, clone 1H7D3, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
ChIP
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Cell Lines
Proteins
Referencia del producto
Descripción
Especie
SMAD4, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human