SLC12A3
solute carrier family 12 (sodium/chloride transporter), member 3
Sinónimos:
NCC, NCCT, TSC
Especie:
Human SLC12A3 (6559), Mouse Slc12a3 (20497), Rat Slc12a3 (54300), sheep SLC12A3 (101120940), domestic guinea pig Slc12a3 (100726300), naked mole-rat Slc12a3 (101704301), Zebrafish slc12a3 (565439), chicken SLC12A3 (415692), dog SLC12A3 (478118), domestic cat SLC12A3 (101082284) ...Más
ID UniProtKB:
ID del gen:
- Human(6559) Summary: This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(20497) solute carrier family 12, member 3
- Rat(54300) solute carrier family 12 (sodium/chloride transporter), member 3
- sheep(101120940) solute carrier family 12 (sodium/chloride transporters), member 3
- domestic guinea pig(100726300) solute carrier family 12 (sodium/chloride transporters), member 3
- naked mole-rat(101704301) solute carrier family 12 (sodium/chloride transporters), member 3
- Zebrafish(565439) solute carrier family 12 (sodium/chloride transporters), member 3
- chicken(415692) solute carrier family 12 (sodium/chloride transporters), member 3
- dog(478118) solute carrier family 12 (sodium/chloride transporters), member 3
- domestic cat(101082284) solute carrier family 12 (sodium/chloride transporters), member 3
- cow(404171) solute carrier family 12 (sodium/chloride transporters), member 3
- Horse(100051953) solute carrier family 12 (sodium/chloride transporters), member 3
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-SLC12A3 Antibody, clone 3I12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-SLC12A3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-SLC12A3 antibody produced in rabbit, 1 mg/mL, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
western blot
Small Molecule - Inhibitor
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Descripción
Especie
Hydrochlorothiazide, Pharmaceutical Secondary Standard; Certified Reference Material,
Especie
human
Chlorothiazide, Pharmaceutical Secondary Standard; Certified Reference Material,
Especie
human
Chlortalidone for system suitability,, European Pharmacopoeia (EP) Reference Standard,
Especie
human
esiRNA
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Especie