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Merck

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Sinónimos:
CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha
Especie:
ID UniProtKB:
ID del gen:
  • Human(5290) Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]
  • Mouse(18706) phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
  • Rat(170911) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • sheep(101110015) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • chicken(424971) phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • dog(488084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic guinea pig(100735084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • naked mole-rat(101711934) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic cat(101097413) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • cow(282306) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-PIK3CA antibody produced in rabbit, ,
Reactividad de especies
human, mouse
Aplicación
immunofluorescence
immunohistochemistry

western blot
Monoclonal Anti-PIK3CA antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL8347, purified immunoglobulin, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
Anti-PIK3CA antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
Anti-PI-3 kinase p110α Antibody, clone 1J4 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, monkey
Aplicación
affinity binding assay
flow cytometry

immunohistochemistry

western blot
Monoclonal Anti-PIK3CA antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL8345, purified immunoglobulin, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
western blot

Cell Lines

Referencia del producto
Descripción
Especie
DLD1 Cells PIK3CA +/-, ,
Especie
human
MCF10A CELLS PTEN (-/-) PIK3CA H1047R (+/-), ,
Especie
human

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
PF-04691502, ≥98% (HPLC),
Especie
human

Proteins

Referencia del producto
Descripción
Especie
PI3 kinase (p110a/p85a) Active human, recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE),
Especie
human
PI3K (p110-α/p85-α), active, His tagged from mouse and human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
mouse
PI3 kinase [p110a(H1047R)/p85a] Active human, recombinant, expressed in baculovirus infected insect cells, ≥60% (SDS-PAGE),
Especie
human
PI3 kinase [p110a(E545K)/p85a] Active human, recombinant, expressed in baculovirus infected insect cells, ≥55% (SDS-PAGE),
Especie
human
PI3K (p110-α/p55-γ), active, His tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human PIK3CA (2),
Especie
human
MISSION® esiRNA, targeting human PIK3CA,
Especie
human
MISSION® esiRNA, targeting mouse Pik3ca,
Especie
mouse