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Merck

MYLK

myosin light chain kinase

Sinónimos:
AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK
Especie:
ID UniProtKB:
ID del gen:
  • Human(4638) Summary: This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
  • Mouse(107589) myosin, light polypeptide kinase
  • Rat(288057) myosin light chain kinase
  • domestic guinea pig(100714177) myosin light chain kinase
  • dog(488012) myosin light chain kinase
  • naked mole-rat(101704236) myosin light chain kinase
  • chicken(396445) myosin light chain kinase
  • Domestic Rabbit(100009143) myosin light chain kinase
  • sheep(443334) myosin light chain kinase
  • cow(338037) myosin light chain kinase
  • Horse(100070482) myosin light chain kinase

Custom & Knockdown Gene Products

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Monoclonal Anti-Myosin Light Chain Kinase antibody produced in mouse, clone K36, ascites fluid,
Reactividad de especies
avian, mammals
Aplicación
immunoprecipitation (IP)
microarray

western blot
Anti-MYLK antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
Anti-MYLK antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reactividad de especies
human
Aplicación
immunofluorescence
Anti-MYLK Antibody, clone 1J2U2, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
ML-7, powder,
Especie
human

Proteins

Referencia del producto
Descripción
Especie
MLCK (1425-1776), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human MYLK (2),
Especie
human
MISSION® esiRNA, targeting mouse Mylk,
Especie
mouse
MISSION® esiRNA, targeting human MYLK (1),
Especie
human