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Merck

KCNQ4

potassium voltage-gated channel, KQT-like subfamily, member 4

Sinónimos:
DFNA2, DFNA2A, KV7.4
Especie:
ID UniProtKB:
ID del gen:
  • Human(9132) Summary: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(60613) potassium voltage-gated channel, subfamily Q, member 4
  • Rat(298496) potassium voltage-gated channel, KQT-like subfamily, member 4
  • chicken(419643) potassium voltage-gated channel, KQT-like subfamily, member 4
  • naked mole-rat(101714294) potassium voltage-gated channel, KQT-like subfamily, member 4
  • domestic guinea pig(100716024) potassium voltage-gated channel, KQT-like subfamily, member 4
  • sheep(101122655) potassium voltage-gated channel, KQT-like subfamily, member 4
  • Domestic Rabbit(100358271) potassium voltage-gated channel, KQT-like subfamily, member 4
  • domestic cat(101091641) potassium voltage-gated channel, KQT-like subfamily, member 4
  • Horse(100067963) potassium voltage-gated channel, KQT-like subfamily, member 4
  • cow(528741) potassium voltage-gated channel, KQT-like subfamily, member 4
  • dog(482451) potassium voltage-gated channel, KQT-like subfamily, member 4

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Small Molecule - Activator

Referencia del producto
Descripción
Especie
BMS 204352, ≥98% (HPLC),
Especie
human

Small Molecule - Blocker

Referencia del producto
Descripción
Especie
Retigabine, analytical standard,
Especie
human
Guanidina hydrochloride, for molecular biology, ≥99%,
Especie
human
Guanidina hydrochloride, ≥98%,
Especie
human
Guanidina hydrochloride, organic base and chaeotropic agent, ≥99% (titration),
Especie
human
Guanidina hydrochloride, ,
Especie
human

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
N-Ethylmaleimide, crystalline, ≥98% (HPLC),
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human KCNQ4,
Especie
human
MISSION® esiRNA, targeting mouse Kcnq4,
Especie
mouse